Installed the following: sudo apt-get install arduino sudo apt-get install gcc-avr binutils-avr avr-libc sudo apt-get install avrdude sudo apt-get install arduino-cli Compile: avr-gcc -Os -mmcu=atmega2560 -c -o blinking_led blinking_led.c Obj Copy: avr-objcopy -O ihex -R .eeprom blinking_led blinking_led.hex Programming: avrdude -C /usr/share/arduino/hardware/tools/avrdude.conf -patmega2560 -cwiring -P /dev/ttyACM0 -b 115200 -D -U flash:w:blinking_led.hex:i